SOP for Solvent Selection and Preparation for Nanoparticle Synthesis

Standard Operating Procedure for Solvent Selection and Preparation for Nanoparticles

1) Purpose

This SOP provides a detailed guideline for selecting, handling, and preparing solvents used in the synthesis of nanoparticle formulations. This ensures the correct solvent is chosen for the desired nanoparticle properties and that solvents are handled safely.

2) Scope

This SOP applies to all staff involved in the preparation, selection, and handling of solvents for nanoparticle synthesis.

3) Responsibilities

Operators: Ensure the correct solvent is chosen, prepared, and handled according to this SOP.
QA: Verify that solvent handling procedures are compliant with safety and quality standards.

4) Procedure

4.1 Solvent Selection

4.1.1 Criteria for Solvent Selection

4.1.1.1 The solvent should be chosen based on the chemical properties of the precursor materials and the required characteristics of the nanoparticle product (e.g., size, stability).
4.1.1.2 Choose solvents with high purity and low volatility unless otherwise specified for specific nanoparticle synthesis processes.

4.2 Solvent Preparation

4.2.1 Solvent Handling

4.2.1.1 Always handle solvents in a fume hood or well-ventilated area to minimize exposure to fumes.
4.2.1.2 Ensure all containers are properly labeled with the solvent name, concentration, and preparation date.

4.2.2 Solvent Dispensing

4.2.2.1 Dispense the required amount of solvent using calibrated equipment (e.g., pipettes or volumetric flasks) to ensure accuracy in formulation.
4.2.2.2 Avoid spillage by using appropriate funnels and sealed containers during solvent transfer.

5) Abbreviations, if any

PPE: Personal Protective Equipment
QA: Quality Assurance

6) Documents, if any

Solvent Preparation Logbook

7) References, if any

MSDS for solvents

8) SOP Version

Version 1.0

Annexure

Solvent Preparation Logbook Template


  
    Date
    Solvent Name
    Concentration
    Volume Prepared
    Operator Initials
    QA Initials
  
  
    DD/MM/YYYY
    Solvent Name
    Concentration %
    Volume in mL
    Operator Name
    QA Name