SOP for Preparation and Handling of Nanoparticle Precursors

Standard Operating Procedure for Handling Nanoparticle Precursors

1) Purpose

This SOP outlines the procedures for the preparation and safe handling of nanoparticle precursors used in the production of nanoparticle formulations. The objective is to ensure proper preparation, safe handling, and prevention of contamination.

2) Scope

This SOP applies to all laboratory staff and operators who are responsible for the preparation and handling of nanoparticle precursors within the laboratory and production areas.

3) Responsibilities

Operators: Responsible for handling and preparing nanoparticle precursors in compliance with this SOP.
QA: Ensures quality of the prepared precursors and compliance with safety guidelines.

4) Procedure

4.1 Preparation of Nanoparticle Precursors

4.1.1 Required Materials

4.1.1.1 Gather all required precursor materials, such as polymers, surfactants, lipids, or metals, depending on the nanoparticle type.
4.1.1.2 Ensure all equipment and containers are cleaned and sanitized according to laboratory guidelines.

4.1.2 Weighing and Dispensing

4.1.2.1 Use a calibrated balance to weigh the exact amounts of precursors as per the formulation batch record.
4.1.2.2 Dispense the required materials into properly labeled containers for each batch.

4.2 Handling of Precursors

4.2.1 Safety Measures

4.2.1.1 Ensure all operators are wearing appropriate personal protective equipment (PPE), including gloves, safety goggles, and lab coats.
4.2.1.2 Work in a fume hood or well-ventilated area when handling volatile or

hazardous chemicals.

4.2.2 Contamination Prevention

4.2.2.1 Use sterile, sealed containers to transport precursors to the production area to prevent cross-contamination.
4.2.2.2 Handle precursors only with sterilized tools to avoid contamination.

4.3 Storage of Nanoparticle Precursors

4.3.1 Storage Conditions

4.3.1.1 Store all nanoparticle precursors at the appropriate temperature (as indicated in the precursor’s material safety data sheet) to maintain stability and prevent degradation.
4.3.1.2 Ensure all containers are labeled with material name, batch number, and date of preparation.

5) Abbreviations, if any

PPE: Personal Protective Equipment
QA: Quality Assurance

6) Documents, if any

Nanoparticle Precursor Preparation Logbook

7) References, if any

Material Safety Data Sheets (MSDS) for nanoparticle precursors

8) SOP Version

Version 1.0

Annexure

Nanoparticle Precursor Preparation Logbook Template


  
    Date
    Material Name
    Batch Number
    Quantity Prepared
    Operator Initials
    QA Initials
  
  
    DD/MM/YYYY
    Precursor Material
    Batch Number
    Quantity in grams
    Operator Name
    QA Name