Skip to content
  • Clinical Studies
  • Schedule M
  • Stability Studies
  • Pharma GMP
  • Pharma Tips
  • Pharma Books
  • Pharma Validation
  • Pharma Regulatory

SOP Guide for Pharma

The Ultimate Resource for Pharmaceutical SOPs and Best Practices

  • Home
  • Job Safety Analysis (JSA)
    • Oral Dosage Forms (Tablets & Capsules)
    • Oral Liquid Dosage Forms (Syrups, Elixirs, Suspensions, Emulsions)
    • Powder and Granule Dosage Forms
    • Topical Dosage Forms (Creams, Ointments, Gels, Lotions, Pastes)
    • Transdermal Dosage Forms (Patches)
  • Standard Test Procedures (STP)
  • SOP – Blog Post
  • Toggle search form

SOP for Dispensing Hazardous Materials

Posted on By

SOP for Dispensing Hazardous Materials

Standard Operating Procedure for Dispensing Hazardous Materials

1) Purpose

The purpose of this SOP is to establish safe and standardized procedures for dispensing hazardous materials to ensure the safety of personnel, prevent contamination, and minimize environmental risks.

2) Scope

This SOP applies to all personnel involved in dispensing hazardous materials in laboratories, storage areas, and production facilities. It includes solid, liquid, and gaseous hazardous substances.

3) Responsibilities

  • Operators: Follow proper dispensing protocols and use required Personal Protective Equipment (PPE).
  • Supervisors: Monitor dispensing operations and ensure compliance with safety guidelines.
  • Safety Officers: Conduct risk assessments, provide safety equipment, and oversee training.
  • Maintenance Team: Maintain dispensing equipment, ventilation systems, and spill kits.

4) Procedure

4.1 Preparation for Dispensing

  1. Material Identification:
    1. Review the Safety Data Sheet (SDS) of the material to identify:
      • Physical and chemical hazards
      • Permissible Exposure Limits (PEL)
      • Reactivity and compatibility
    2. Label all containers being used for dispensing clearly with:
      • Material name
      • Hazard classification
      • Precautionary warnings
  2. php
    Copy code

  3. Preparation of Dispensing Area:
    1. Conduct all dispensing operations in designated areas with proper ventilation (e.g., fume hoods or ventilated cabinets).
    2. Ensure spill kits and emergency eyewash stations are nearby and functional.
    3. Remove any ignition sources (open flames, sparks) when working with flammable materials.
  4. Personal Protective Equipment (PPE):
    1. Wear appropriate PPE based on the material’s hazard level:
      • Chemical-resistant gloves
      • Safety goggles or face
shields
  • Respirators for inhalation hazards
  • Lab coats or chemical-resistant aprons
  • Verify the PPE is intact, clean, and suitable for the material being dispensed.
  • Equipment Readiness:
    1. Inspect all dispensing equipment (e.g., pumps, funnels, drip trays) for leaks, cracks, or malfunctions.
    2. Use only tools and containers compatible with the hazardous material (e.g., non-reactive containers for acids).
    3. Ensure secondary containment trays are in place for liquids.
  • 4.2 Dispensing Procedure

    1. General Dispensing Guidelines:
      1. Always dispense hazardous materials slowly to prevent spills, splashes, or vapor release.
      2. Do not overfill containers; leave sufficient headspace to allow for material expansion.
      3. Use funnels and pumps to transfer liquids; avoid direct pouring whenever possible.
    2. less
      Copy code

    3. Dispensing Flammable Liquids:
      1. Dispense flammable liquids in designated areas free of ignition sources.
      2. Use grounded or bonded containers to prevent static electricity buildup.
      3. Ensure that containers are tightly sealed immediately after dispensing.
    4. Dispensing Corrosive Materials:
      1. Use chemical-resistant pumps or equipment for acids and bases.
      2. Handle corrosive materials under a fume hood to avoid vapor inhalation.
      3. Rinse external surfaces of containers after dispensing to prevent residual contamination.
    5. Dispensing Toxic Gases:
      1. Handle toxic gases only in properly ventilated gas cabinets or fume hoods.
      2. Use compatible regulators and leak detectors to ensure connections are airtight.
      3. Monitor gas levels using portable gas detection devices.
    6. Dispensing Powders and Granular Materials:
      1. Work under localized exhaust systems to prevent dust exposure.
      2. Use scoopers and tools made of non-reactive materials.
      3. Wear respirators to protect against inhalation of particulates.

    4.3 Post-Dispensing Activities

    1. Securing Materials:
      1. Ensure containers are sealed properly and labeled clearly before returning to storage.
      2. Store materials in designated areas, maintaining segregation for incompatible chemicals.
    2. less
      Copy code

    3. Decontamination:
      1. Clean all tools and dispensing equipment using appropriate neutralizing or cleaning agents.
      2. Dispose of PPE, wipes, or absorbents contaminated with hazardous materials as hazardous waste.
    4. Waste Management:
      1. Collect all waste material in designated hazardous waste containers.
      2. Label waste containers with the material name, hazard class, and date.
      3. Dispose of waste according to facility guidelines and regulatory requirements.

    4.4 Emergency Protocols

    1. Spill Management:
      1. Stop dispensing operations immediately and secure the area.
      2. Use spill kits to contain minor spills; report large spills to the Safety Officer immediately.
    2. less
      Copy code

    3. Exposure to Hazardous Material:
      1. Skin contact: Remove contaminated clothing and rinse the affected area with water for 15 minutes.
      2. Eye contact: Flush eyes using an eyewash station for at least 15 minutes.
      3. Inhalation: Move to fresh air and seek medical assistance if symptoms persist.
    4. Fire Emergency:
      1. Activate the fire alarm and evacuate the area immediately.
      2. Use Class B fire extinguishers for flammable liquids if trained to do so.
      3. Contact emergency services and provide details of the material involved.

    5) Abbreviations, if any

    • SDS: Safety Data Sheet
    • PPE: Personal Protective Equipment

    6) Documents, if any

    • Hazardous Material Dispensing Log
    • Incident Reports
    • Safety Data Sheets (SDS)

    7) Reference, if any

    • OSHA Hazard Communication Standard (29 CFR 1910.1200)
    • NFPA Guidelines for Safe Handling of Flammable and Hazardous Chemicals

    8) SOP Version

    Version: 1.0

    Annexure

    Template 1: Hazardous Material Dispensing Log

     
    Date Material Name Quantity Dispensed Handled By Remarks
    DD/MM/YYYY Material Name XX Liters/Grams Employee Name Process Completed
    See also  SOP for Documenting Routine EHS Audits
    Environment, Health and Safety Tags:Emergency response for hazardous materials incidents, Hazardous materials classification, Hazardous materials compliance audits, Hazardous materials decontamination procedures, Hazardous materials disposal methods, Hazardous materials emergency planning, Hazardous materials emergency response guidebook, Hazardous materials exposure limits, Hazardous materials handling, Hazardous materials handling equipment, Hazardous materials incident command system, Hazardous materials incident reporting, Hazardous materials inventory management, Hazardous materials labeling requirements, Hazardous materials monitoring equipment, Hazardous materials packaging requirements, Hazardous materials placarding requirements, Hazardous materials regulatory agencies, Hazardous materials response team training, Hazardous materials risk assessment, Hazardous materials security plans, Hazardous materials shipping papers, Hazardous materials spill response, Hazardous materials storage guidelines, Hazardous materials training requirements, Hazardous materials transportation regulations, Hazardous materials transportation safety, Personal protective equipment for hazardous materials, Regulatory compliance in hazardous materials management, Safety procedures for hazardous materials

    Post navigation

    Previous Post: SOP for Handling Toxic Gases in the Facility
    Next Post: SOP for Checking Raw Material Consignment for Transport Damages – V 2.0

    Standard Operating Procedures V 1.0

    • Aerosols
    • Analytical Method Development
    • Bioequivalence Bioavailability Study
    • Capsule Formulation
    • Clinical Studies
    • Creams
    • Data Integrity
    • Dental Dosage Forms
    • Drug Discovery
    • Environment, Health and Safety
    • Formulation Development
    • Gels
    • Good Distribution Practice
    • Good Warehousing Practices
    • In-Process Control
    • Injectables
    • Liquid Orals
    • Liposome and Emulsion Formulations
    • Lotions
    • Lyophilized Products
    • Maintenance Dept.
    • Medical Devices
    • Metered-Dose Inhaler
    • Microbiology Testing
    • Nanoparticle Formulation
    • Nasal Spray Formulations
    • Nebulizers
    • Ocular (Eye) Dosage Forms
    • Ointments
    • Otic (Ear) Dosage Forms
    • Pharmacovigilance
    • Powder & Granules
    • Purchase Departments
    • Quality Assurance
    • Quality Control
    • Raw Material Stores
    • Regulatory Affairs
    • Tablet Manufacturing
    • Rectal Dosage Forms
    • Transdermal Patches
    • Vaginal Dosage Forms
    • Validations and Qualifications

    Read SOPs in your Language:

     - 
    Bengali
     - 
    bn
    English
     - 
    en
    Gujarati
     - 
    gu
    Hindi
     - 
    hi
    Malayalam
     - 
    ml
    Marathi
     - 
    mr
    Punjabi
     - 
    pa
    Tamil
     - 
    ta
    Telugu
     - 
    te

    NEW! Revised SOPs – V 2.0

    • Aerosols V 2.0
    • Analytical Method Development V 2.0
    • API Manufacturing V 2.0
    • BA-BE Studies V 2.0
    • Biosimilars V 2.0
    • Capsules V 2.0
    • Creams V 2.0
    • Elixers V 2.0
    • Ointments V 2.0
    • Raw Material Warehouse V 2.0
    • Tablet Manufacturing V2.0

    New Publication: A must for All.

    Copyright © 2025 SOP Guide for Pharma.

    Powered by PressBook WordPress theme

    Go to mobile version