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Elixir Department: SOP for Troubleshooting Electrical Failures in Machines – V 2.0

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Elixir Department: SOP for Troubleshooting Electrical Failures in Machines – V 2.0

Standard Operating Procedure for Troubleshooting Electrical Failures in Machines in Elixir Manufacturing

Department Elixir Department
SOP No. SOP/ELX/160/2025
Supersedes SOP/ELX/160/2022
Page No. Page 1 of 10
Issue Date 11/04/2025
Effective Date 15/04/2025
Review Date 11/04/2026

1. Purpose

To define the procedure for systematically identifying, isolating, rectifying, and documenting electrical failures in machines used within the Elixir Department to ensure equipment uptime, process continuity, and electrical safety.

2. Scope

This SOP covers all elixir manufacturing machines such as mixers, transfer pumps, filling units, and control panels that operate on electrical systems, including power distribution panels and automation circuits.

3. Responsibilities

  • Production Operator:
    • Immediately stop the equipment and notify engineering upon detecting an electrical fault.
    • Ensure no attempt is made to reset or troubleshoot on their own.
  • Engineering Electrician/Technician:
    • Perform troubleshooting and corrective action using appropriate PPE and lockout/tagout procedures.
    • Document root cause, repairs, and testing status.
  • QA Officer:
    • Review and approve equipment release post-troubleshooting for GMP resumption.
See also  Elixir Department: SOP for Dispensing Light Sensitive Materials - V 2.0

4. Accountability

The Engineering Head is accountable for electrical fault resolution. The Production Head ensures proper communication and stoppage. The QA Head is

responsible for validation and batch impact review.

5. Procedure

5.1 Initial Response

  1. Operator shall:
    • Stop the machine immediately using the emergency stop (E-STOP) if needed.
    • Switch off main power and display “DO NOT OPERATE” tag.
    • Inform Engineering and QA teams.

5.2 Troubleshooting by Engineering

  1. Ensure lockout/tagout is applied before panel or component access.
  2. Inspect:
    • MCBs, fuses, relays, and contactors for tripping or burnout
    • Loose wires, faulty connectors, moisture, or damaged cables
    • PLC/HMI faults and system diagnostic logs
  3. Use multimeter, continuity tester, or IR thermometer for diagnostics.
  4. Replace damaged components with spares from approved list.
  5. Conduct test run after corrective action with power ON, without product batch.
See also  Elixir Department: SOP for Homogeneity Verification - V 2.0

5.3 Documentation and Reporting

  1. Fill the Electrical Fault Log (Annexure-1) with:
    • Date, time, equipment ID, nature of failure
    • Root cause analysis and corrective actions
    • Name of technician and QA reviewer
  2. Update the Equipment History Card with service details.
  3. Attach photos of damaged components, if applicable.

5.4 Post-Repair Equipment Release

  1. QA shall verify functionality, cleanliness, and system calibration.
  2. If batch was interrupted, perform impact assessment before restarting process.
  3. Resume batch operations only after QA signs off the Equipment Release Form.

6. Abbreviations

  • SOP: Standard Operating Procedure
  • QA: Quality Assurance
  • MCB: Miniature Circuit Breaker
  • PLC: Programmable Logic Controller
  • HMI: Human Machine Interface

7. Documents

  1. Electrical Fault Log (Annexure-1)
  2. Equipment History Card
  3. Equipment Release Form
See also  Elixir Department: SOP for Calibration of Temperature Probes - V 2.0

8. References

  • 21 CFR Part 211 – Equipment Maintenance Requirements
  • IS 5216 – Electrical Safety Practices
  • WHO TRS 1010 – Pharmaceutical Utilities and Equipment Guidelines

9. SOP Version

Version: 2.0

10. Approval Section

Prepared By Checked By Approved By
Signature
Date
Name
Designation
Department

11. Annexures

Annexure-1: Electrical Fault Log

Date Equipment ID Nature of Fault Root Cause Corrective Action Technician QA Review
11/04/2025 MXR-ELX-07 HMI Not Powering On Loose Connector Reseated & secured Ramesh Nair Sunita Reddy

Revision History:

Revision Date Revision No. Revision Details Reason for Revision Approved By
01/01/2024 1.0 Initial SOP Release New SOP QA Head
11/04/2025 2.0 Added photos and technician acknowledgment fields Improved Documentation QA Head
Elixers V 2.0 Tags:Elixir colorants, Elixir dosage form, Elixir filtration techniques, Elixir flavoring agents, Elixir formulation, Elixir GMP compliance, Elixir manufacturing process, Elixir manufacturing SOPs, Elixir packaging requirements, Elixir pharmacopoeial standards, Elixir preparation methods, Elixir preservatives, Elixir production equipment, Elixir quality control, Elixir regulatory guidelines, Elixir shelf life, Elixir stability testing, Elixir sterilization methods, Elixir storage conditions, Elixir sweetening agents, Elixir viscosity modifiers, Hydroalcoholic solutions, Medicated elixirs, Non-medicated elixirs, Pharmaceutical elixirs

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Standard Operating Procedures V 1.0

  • Aerosols
  • Analytical Method Development
  • Bioequivalence Bioavailability Study
  • Capsule Formulation
  • Clinical Studies
  • Creams
  • Data Integrity
  • Dental Dosage Forms
  • Drug Discovery
  • Environment, Health and Safety
  • Formulation Development
  • Gels
  • Good Distribution Practice
  • Good Warehousing Practices
  • In-Process Control
  • Injectables
  • Liquid Orals
  • Liposome and Emulsion Formulations
  • Lotions
  • Lyophilized Products
  • Maintenance Dept.
  • Medical Devices
  • Metered-Dose Inhaler
  • Microbiology Testing
  • Nanoparticle Formulation
  • Nasal Spray Formulations
  • Nebulizers
  • Ocular (Eye) Dosage Forms
  • Ointments
  • Otic (Ear) Dosage Forms
  • Pharmacovigilance
  • Powder & Granules
  • Purchase Departments
  • Quality Assurance
  • Quality Control
  • Raw Material Stores
  • Regulatory Affairs
  • Tablet Manufacturing
  • Rectal Dosage Forms
  • Transdermal Patches
  • Vaginal Dosage Forms
  • Validations and Qualifications

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NEW! Revised SOPs – V 2.0

  • Aerosols V 2.0
  • Analytical Method Development V 2.0
  • API Manufacturing V 2.0
  • BA-BE Studies V 2.0
  • Biosimilars V 2.0
  • Capsules V 2.0
  • Creams V 2.0
  • Elixers V 2.0
  • Gels V 2.0
  • Injectables V 2.0
  • Ointments V 2.0
  • Raw Material Warehouse V 2.0
  • Tablet Manufacturing V2.0

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