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Aerosol: SOP for Determining Spray Angle and Coverage of Aerosols – V 2.0

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Aerosol: SOP for Determining Spray Angle and Coverage of Aerosols – V 2.0

Procedure for Determining Spray Angle and Coverage of Aerosol Products

Department Aerosol
SOP No. SOP/Aerosol/194/2025
Supersedes SOP/Aerosol/194/2022
Page No. Page 1 of Y
Issue Date 06/02/2025
Effective Date 16/02/2025
Review Date 06/02/2028

1. Purpose

The purpose of this Standard Operating Procedure (SOP) is to establish a validated method for measuring the spray angle and coverage of aerosol products to ensure uniform dispersion and product efficacy.

2. Scope

This SOP applies to all aerosol formulations tested for spray pattern, angle, and coverage within the Quality Control (QC) laboratory and during in-process monitoring.

3. Responsibilities

  • Quality Control (QC) Analysts: Responsible for conducting spray angle and coverage tests.
  • Quality Assurance (QA) Team: Responsible for reviewing and approving test results.
  • Laboratory Supervisor: Responsible for ensuring compliance with the validated test method.
  • Production Team: Responsible for providing representative samples for testing.
See also  Aerosol: SOP for Documenting Cleaning Validation Activities - V 2.0

4. Accountability

The Quality Control Manager is accountable for ensuring the accuracy and reliability of spray angle and coverage testing.

5. Procedure

5.1. Sample Preparation

  1. Randomly select aerosol cans from the batch.
  2. Ensure cans are conditioned at room temperature before testing.
  3. Record sample details in the Spray Test Sample Log (Annexure-1).

5.2. Spray Angle Measurement

  1. Use a calibrated spray pattern analysis system or a protractor-based setup.
  2. Spray the aerosol onto a flat surface from a standard distance (e.g., 15 cm).
  3. Measure the angle of dispersion from
the central axis.
  • Record results in the Spray Angle Test Log (Annexure-2).
  • 5.3. Spray Coverage Assessment

    1. Apply spray to a pre-marked surface with grid lines.
    2. Allow the formulation to settle and measure the coverage area.
    3. Compare the results against product specifications.
    4. Record measurements in the Spray Coverage Test Log (Annexure-3).

    5.4. Data Analysis and Acceptance Criteria

    1. Compare test results with predefined specifications.
    2. Identify any deviations and assess potential impact on product performance.
    3. Document findings in the Spray Performance Report (Annexure-4).

    5.5. Corrective Actions for Non-Conforming Results

    1. Investigate root causes for abnormal spray angles or uneven coverage.
    2. Recommend corrective actions such as valve adjustment or formulation modification.
    3. Document corrective measures in the Spray Test Corrective Action Log (Annexure-5).

    6. Abbreviations

    • GMP: Good Manufacturing Practice
    • QC: Quality Control
    • QA: Quality Assurance
    • SOP: Standard Operating Procedure

    7. Documents

    1. Spray Test Sample Log (Annexure-1)
    2. Spray Angle Test Log (Annexure-2)
    3. Spray Coverage Test Log (Annexure-3)
    4. Spray Performance Report (Annexure-4)
    5. Spray Test Corrective Action Log (Annexure-5)

    8. References

    • Good Manufacturing Practice (GMP) Guidelines
    • ISO Standards for Aerosol Spray Performance
    • FDA Guidelines on Aerosol Dispersion Testing

    9. SOP Version

    Version: 2.0

    10. Approval Section

    Prepared By Checked By Approved By
    Signature
    Date
    Name
    Designation
    Department

    11. Annexures

    Annexure-1: Spray Test Sample Log

    Batch No. Sample ID Test Date Analyst
    BN-235 SPL-201 07/02/2025 Rahul Mehta

    Annexure-2: Spray Angle Test Log

    Sample ID Spray Distance (cm) Spray Angle (°) Checked By
    SPL-201 15 cm 45° QA Team

    Annexure-3: Spray Coverage Test Log

    Sample ID Coverage Area (cm²) Test Method Reviewed By
    SPL-202 120 cm² Grid Marking QA Team

    Annexure-4: Spray Performance Report

    Batch No. Test Parameter Specification Result Approved By
    BN-236 Spray Angle 40°-50° 45° QA Team

    Annexure-5: Spray Test Corrective Action Log

    Issue Identified Corrective Action Implementation Date Approved By
    Spray Angle Out of Range Valve Adjustment 08/02/2025 Anjali Sharma

    12. Revision History:

    Revision Date Revision No. Revision Details Reason for Revision Approved By
    01/01/2024 V 1.0 Initial Release First Issue Anjali Sharma
    01/01/2025 V 2.0 Updated spray testing parameters GMP Compliance Anjali Sharma
    See also  Aerosol: SOP for Reporting and Reviewing Validation Data - V 2.0
    Aerosols V 2.0 Tags:Aerosol Batch Production, Aerosol Can Design, Aerosol Cold Filling, Aerosol Documentation Standards, Aerosol Emissions Control, Aerosol Environmental Regulations, Aerosol equipment calibration, Aerosol Filling Process, Aerosol Fire Safety Measures, Aerosol Formulation, Aerosol Good Manufacturing Practice (GMP), Aerosol Hazardous Materials Handling, Aerosol Incident Reporting, Aerosol Leak Testing, Aerosol Maintenance Schedules, Aerosol Personal Protective Equipment (PPE), Aerosol Pressure Filling, Aerosol Product Labeling, Aerosol Product Testing, Aerosol Propellant Selection, Aerosol quality control, Aerosol Regulatory Compliance, Aerosol Risk Assessment, Aerosol Safety Protocols, Aerosol Standard Operating Procedures (SOPs), Aerosol Storage Requirements, Aerosol Training Programs, Aerosol Valve Crimping, Aerosol Ventilation Systems, Aerosol Waste Disposal

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    Standard Operating Procedures V 1.0

    • Aerosols
    • Analytical Method Development
    • Bioequivalence Bioavailability Study
    • Capsule Formulation
    • Clinical Studies
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